Product Overview
The Waters ACQUITY UPLC M-Class μBinary Solvent Manager is a high-precision, dual-piston solvent delivery pump engineered for ultra-performance liquid chromatography (UPLC) systems. Manufactured by Waters Corporation, this binary solvent manager utilizes two independent, servo-controlled axial piston pump heads to deliver mobile phase gradients at micro-flow rates with exceptional compositional accuracy and pulse-free flow stability. As the core fluid delivery module within the ACQUITY UPLC M-Class platform, it enables nanoscale and capillary-scale separations by precisely metering two solvent streams under high system backpressure, making it indispensable for proteomics, biomarker discovery, and high-sensitivity pharmaceutical analysis workflows.
Technical Specifications
| Parameter | Specification / Feature |
|---|---|
| Component Type | Hydraulic Piston Pump (Binary Solvent Delivery) |
| Model Designation | ACQUITY UPLC M-Class μBinary Solvent Manager |
| Operating Pressure | Up to 15,000 psi (1,034 bar) system pressure |
| Mounting & Connection | Waters ACQUITY UPLC M-Class system interface; standard 1/16″ and micro-bore fittings |
| Pump Configuration | Dual independent axial piston pump heads (binary gradient) |
| Flow Rate Range | Micro-flow range (typically 1 µL/min to 100 µL/min) |
| Gradient Accuracy | ±0.5% absolute, high compositional precision |
| Control Interface | Integrated with Waters Empower / MassLynx software |
Engineering Features & Advantages
- Precision Performance: Dual servo-controlled axial piston pump heads deliver pulse-free, highly reproducible micro-flow gradients with exceptional retention time stability, critical for nanoscale LC-MS separations.
- Industrial Reliability: Built for continuous operation under high-pressure chromatographic conditions, with robust piston and seal design that minimizes wear and maintains flow accuracy over extended duty cycles.
- Direct Fit Replacement: Exact dimensional and functional compatibility with the Waters ACQUITY UPLC M-Class platform, ensuring seamless integration and minimal system downtime.
- Advanced Gradient Control: Independent pump head actuation enables precise binary solvent blending, supporting complex gradient methods with low delay volume.
- Micro-Flow Capability: Optimized for capillary and nano-scale chromatography, reducing solvent consumption while maximizing sensitivity for limited-sample applications.
Typical Industrial Applications
This binary solvent delivery pump is deployed in high-sensitivity analytical and industrial environments, including pharmaceutical and biopharmaceutical research and development, proteomics and biomarker discovery laboratories, clinical diagnostics and toxicology screening, and ultra-trace environmental and food safety analysis. It is also integral to academic and government research institutions performing advanced LC-MS/MS workflows requiring precise micro-flow gradient delivery.
PRODUCT IMAGES

Waters ACQUITY UPLC M-Class μBinary Solvent Manager UPLC Binary Solvent Delivery Pump
⚡ Emergency Plant Maintenance & Ready-to-Ship Notice:
- Authentic & Fully Tested: 100% bench tested for hydraulic response, pressure rating, and null-bias stability before dispatch.
- Fast Dispatch: In-stock units ready for same-day dispatch via DHL / FedEx Express directly to your plant.
- Pre-Shipment Verification: High-definition photos, video testing runs, and serial number verification provided prior to shipment.
- Peace of Mind: Covered by our 12-Month Replacement Warranty.
Shop the genuine Waters ACQUITY UPLC M-Class μBinary Solvent Manager. This US-made microfluidic component features a binary solvent delivery system, delivering leak-free, reliable fluid control for heavy-duty industrial systems.